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Stem Cell Research
In 1998,
researchers at the University of
Wisconsin successfully harvested the
first stem cell from a living human
embryo. Embryonic stem cells come from
human embryos and form in the first few
days of human development before
individual cells receive their “assignment”
- for example, before they turn into
blood, brain or hair cells. Scientists
speculate that these immature (or blank)
cells can easily be coaxed into becoming
any number of cell types, thereby
holding great promise for healing the
human body, with possible cures for
diabetes and heart disease, to
treatments for burns and spinal-cord
injuries. However, harvesting these
cells comes at a tremendous price: a
living human embryo must be destroyed.
Embryonic Stem Cell
Pitfalls
Despite
what you may hear in the media,
embryonic stem cells have yet to
demonstrate any therapeutic benefit to
patients. Speculation as to the healing
power of embryonic stem cells is just
that: speculation. There is evidence
that embryonic stem cells are difficult
to control what type of cell they turn
into, potentially putting patients who
are treated with these cells at risk for
serious side effects. The major worry of
scientists in working with embryonic
stem cells is this possibility of wild,
undifferiated growth. We call these
tumors.
In 1996,
the Journal Neurology, reported
that fetal tissue injected into a
patient’s brain produced transcient
improvement, but within two years the
patient developed a brain tumor and
died. An autopsy revealed that the fetal
cells had taken root, but had then
metamorphed into other types of human
tissue—hair, skin and bone. These grew
into a tumor, which killed the patient.
A major
publicized development in treating
Parkinsonism was the wild growth of
implanted cells in the brain causing
irreversible and totally disabling
involuntary movements on the part of the
patient. The New England Journal of
Medicine reported that in most cases
the injection of the embryonic nerve
cells into the brains of Parkinson’s
victims had very little or no effect. To
quote the New York Times’ Gina
Kolata, this “not only failed to
show an overall benefit, but also
revealed a disastrous side effect in
about 15% of patients… The cells
apparently grew too well, churning out
so much of the chemical that controls
movement that the patients writhed and
jerked uncontrollably.” Dr. Paul
Green, a Columbia University
neurologist, was quoted in the New
England Journal, “The
uncontrollable movements some patients
suffered were absolutely devastating.
They chew constantly, their fingers go
up and down, and their wrists flex and
distend. [The patients] writhe and
twist, jerk their heads, fling their
arms about. It is tragic, catastrophic,
a real nightmare. And we cannot
selectively turn it off.”
“Any therapies based on the use of
human embryonic stem cells are still
hypothetical and highly experimental.” -
US National Institutes of Health
Another Choice—Adult
Stem Cells
However,
there is another basic type of stem
cells. Adult stem cells come from a
variety of sources, including the
placenta, umbilical-cord blood, brain
tissue, skin, bone marrow and body fat.
Harvesting these cells requires no
destruction of human life.
The use of
adult stem cells in medical treatment is
not new and has a proven track record of
helping patients in the healing process.
For years, leukemia patients have
obtained adult stem cells through
bone-marrow transplants, and cancer
patients often receive their own “cleansed”
stem cells after chemotherapy.
Adult stem
cells have been transformed into
cartilage, muscle, bone, nerve cells,
liver, heart cells, blood vessels, and
almost certainly will shortly be
transformed into kidney, lung, intestine
and central nervous system cells.
The New
England Journal of Medicine reported
that surgeons in Taiwan have restored
vision to patients using stem cells from
the patients’ own eyes.
The Journal
Science reported on two studies
showing that adult stem cells from bone
marrow transplanted into the brains of
mice can develop into nerve cells.
The Journal
Nature again reported that adult
stem cells from bone marrow injected
into damaged mouse hearts became
functional heart muscle cells, partly
restoring the ability of the heart to
pump.
The
Neurological Institute affiliated with
McGill University in Montreal, Canada,
has recently announced that scientists
there have isolated stem cells on the
skin of adult mice, cells that can grow
into brain cells.
Other
reports show that bone marrow stem cells
are being changed into liver cells, skin
cells are being changed into heart
cells, and cord blood promising to
possibly create neural cells. In August
of 2001, several papers reported on four
different medical studies showing early
success with adult stem cells and
umbilical cord blood.1
A
breakthrough from the University of
Minnesota reports finding an adult stem
cell that can turn into every single
tissue of the body. If confirmed, this
means that cells from your own body can
be turned into perfectly matched
replacement tissues and possibly even
organs. These cells show no signs of
aging and do not form cancerous tumors
when injected into adults.
In Ottawa,
Canada doctors have used adult stem
cells to treat multiple sclerosis. The
cells were taken from the bone marrow of
four individual patients. The doctors
then destroyed the patients’ immune
systems with chemotherapy. They injected
the stem cells into their bodies, which
took hold and regenerated the immune and
blood-forming systems of those four
patients. Six months later, the first
patient was found to have no evidence of
multiple sclerosis on MRI scans. The
other three cases followed with similar
results.
Dr.
Catherine Verfaillie at the University
of Minnesota Stem Cell Institute took
stem cells from 10 people ages 2 to 55.
She cultured the cells in test tubes,
along with growth factors and hormones.
Within three weeks, the cells began
behaving like liver cells. She stated, “The
final product had the form of liver
cells and all the proteins you would
expect in liver cells. We tested seven
different functions and they did them
all.”
On May 1,
2002, in the journal Nature
Technology, scientists from Norway
and the U.S. described how they have
taken ordinary skin cells and, without
the use of cloning techniques or
embryonic stem cells, transformed them
into T cells—these are key immune
system cells. “The message here is
that we’re developing an entirely new
approach to tissue replacement therapy
that avoids the issues related to
cloning and embryonic stem cell
research...it shows that tissues can be
generated from adult cells without the
need to destroy embryos.” This
could replace the entire effort now
being generated through stem cells and
cloning.
Overall,
hundreds, perhaps thousands of patients
have already been treated using their
own adult stem cells. A host of treated
diseases have included liver, autoimmune
diseases, cartilage and bone damage,
reversal of diabetes, repair of hearts,
cancers, stroke, and the list goes on.
Adult stem cell biology is advancing at
an incredible rate, as advances are
occurring literally every month.
Non-Destructive
Embryonic Research
Scientists
from Boston’s Children’s Hospital
reported at the American College of
Surgeons Meeting on October 10, 2001,
that they found “early stage embryonic
cells” in the amniotic fluid of
pregnant women. Just two milliliters of
amniotic fluid can provide up to 20,000
cells, 80% of which are viable. When “scaffolded”
together in a lab culture, the cells
quickly grew into connective tissue,
which could be used as tissue grafts to
repair birth defects such as holes in
the abdomen or chest of an unborn child.
So What About Funding?
So why all
the attention on embryonic stem cells
research and its funding? Out of the
fifteen major companies now engaged in
stem cell research, only two are
involved in embryonic stem cells. The
fact that there is very little private
money being invested in embryonic stem
cell research speaks rather loudly. Forbes
Financial Magazine, in their
September 3, 2001 issue, commented that,
“Private research money has gone
overwhelmingly to non-embryo stem cell
research. This is one reason embryo
researchers want to get their hands on
federal funds.”
The
Story Behind Embryonic Research
Major
pharmaceutical and medical companies,
with their billions of dollars they risk
on research of new products and
medicines each year, have not committed
any money to this reputedly
groundbreaking area of embryonic stem
cell research.
To better
understand their silence, it is
important to understand the tiny, but
most vocal, Geron Corporation. According
to the Wall Street Journal, “No
company stands to gain so much from stem
cell research as Geron.”
Geron was
founded in 1992 to find ways to reverse
the aging process. Their initial
research on cells suggested there might
be ways to lengthen the life of
individual cells and, by extension,
potentially human lives. An enormous
wave of publicity followed.
In 1997,
they cloned the gene for the human
telomerase catalytic protein. Revenues,
mostly from collaborative agreements,
not product sales, were approximately
$5,000,000, while losses were nearly
twice that. They sold additional shares
to fund their work. A couple years
later, Geron acquired the cloning
technology which produced “Dolly”
the sheep. Unfortunately for Geron,
because they still had no product,
revenues remained flat, but losses
ballooned to over $45,000,000 in 1999.
So what is
a struggling biotech company to do? They
have to raise more capital or perish. So
they hit the road and put on what is
known in the investment industry as a
“dog and pony show,” with their
pitch concentrated on stem cells derived
from human embryos as a potential
cure-all for disease. They were soon
joined by the pro-abortion crowd, ever
eager to find another chance to
dehumanize life and paint pro-lifers as
insensitive to human pain and suffering.
A sympathetic media took up the “debate”
and ailing movie stars like Christopher
Reeve, Mary Tyler Moore and Michael W.
Fox testified to the need for federal
research support. And it was off to
Washington where Dr. Thomas Okarma of
Geron got what he wanted—federal
funding.
“It is unlikely for both practical
and biologic reasons that
transplantations of fragments of
embryonic tissue will be the therapy of
the future.” -New England Journal of Medicine
A President’s
Decision 
When
President George W. Bush took office in
2001, he put a moratorium on the
research guidelines adopted by the
Clinton administration about federally funding
embryonic stem cell research so that he
could study the problem. That summer,
President Bush came to a decision. To
quote directly from his speech, he
stated that his policy “allows us
to explore the promise and potential of
stem cell research without crossing a
fundamental moral line by providing
taxpayer funding that would sanction or
encourage further destruction of human
embryos…” 2
In
addition, the President issued a strong
call for the medical community to step
up its efforts to conduct research
involving adult stem cells, placentas
and umbilical cord blood.
However, we
now find out that, in 1993, Congress
passed a law prohibiting the President
from banning funding for fetal tissue
research. During the Clinton
administration, such research was done
using federal funds for research
involving stem cells obtained from
aborted babies. The National Institutes
of Health, since 1993, has apparently
funded many experiments involving fetal
tissue from induced abortions. So
apparently, in order to allow the Bush
administration to block such fetal
tissue research funding, Congress would
first have to overturn the 1993 law. It
is doubtful whether this could be
possible at this time.
- Debra Sherman, “Own Stem Cells
Benefit Autoimmune Patients,” The
San Diego Union-Tribune, 12 Aug.
2001; “Singapore Scores Medical
First In Treatment of Thalassaemia,”Agence France Presse, 14 Aug.
2001; Alex Dominguez, “Researchers
Find WayTo Sieve Stem Cells From
Mouse Brains,” the Associated
Press, 15 Aug. 2001; “Stem
Cells Isolated From Skin In Animal
Study,” Reuters, Aug. 2001.
- “Text of Bush’s Stem
Cell Speech,” The Associated
Press, 9 Aug. 2001
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